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But, if we get so starving that our fat levels decrease, no more leptin is made, and we start feeling really hungry once more. We were interested to see if the negative effects of eating poorly in early life could be reversed by eating a healthier diet as we get older. For most scientific studies, it is pretty hard to look inside a human brain to find out what is going on. So, feeding 12 babies is normal for a rat mother. Leptin comes out of the fat in the body and tells us to stop feeling hungry. So, when the baby is developing, ghrelin and leptin do a different job. Ghrelin ends up in the brain and tells the brain to feel hungry and start eating. They found that once babies are past the right time for the hypothalamus to develop there is nothing that can be done to get these feeding neurons to grow properly [ 4 ].

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