Establishment and reactivation of latent herpesvirus infections. Years later, the virus may reactivate, and the distribution of lesions in the skin corresponds closely to areas of innervation dermatome from an individual dorsal root ganglion Fig. Persistent Infections by Organ System Some viruses can establish persistent infection at the same time in different cell types of one or more tissues or organs. Host regulatory mechanisms also are important in modulating HIV expression and replication. For example, AdV can persist latently for years in adenoids and tonsils and often are shed in the feces for many months after the initial infection. Budding of virus particles into cytoplasmic vacuoles, resulting in masked virus production.
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