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Skin Pharmacol Physiol 22 : — Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Alterations of the organization and structure of type I collagen, the most abundant structural protein in skin, is a hallmark of both chronologically aged and photoaged human skin Fig. Aging-associated sensory neuropathy alters pressure-induced vasodilation in humans. The functional consequences of these changes in photoaged skin remain hypothetical Legat and Wolf , Over time, fragmented collagen fibril remnants accumulate and become readily observable in photoaged Varani et al. Photosensitivity in the elderly.

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