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Future study is needed to show how hormones integrate diet, bile acid signaling, and gut microbiota in the gut-to-liver axis to determine sex disparities in metabolic diseases. The gut microbiota and its relationship to diet and obesity: new insights. Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes. G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Among all bile acids, deoxycholic acid has the highest bactericidal activity. Bile acids are steroid-derived amphipathic molecules that act as detergents for absorption of nutrients, steroids, and drugs in the intestine, and also as serve as signaling molecules that activate nuclear farnesoid X receptor FXR and the membrane G-protein bile acid receptor-1 Gpbar-1, aka TGR5. Sex differences in liver cancer and metabolic diseases have been recognized; males have higher prevalence and a higher death rate than females. Author information Article notes Copyright and License information Disclaimer. Bile acids: regulation of synthesis.

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