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To date this hypothesis has not been tested in the IAS of a large animal such as dog or monkey. Biochem Biophys Res Commun. Mechanisms controlling normal defecation and the potential effects of spinal cord injury. Vasoactive intestinal peptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Transmitter interactions in rabbit internal anal sphincter. Published online Apr Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter. Sample traces of the contractile activity recorded from the monkey IAS C and rectum D before and after addition of nifedipine. The IAS is also innervated by inhibitory motor neurons.

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